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Frequency and clinical implications of delayed nausea and delayed emesis
G R Morrow1, J T Hickok, T G Burish
1University of Rochester Cancer Center, New York, USA.
American Journal of Clinical Oncology
|April 1, 1996
Summary
Delayed nausea and vomiting are common chemotherapy side effects occurring more than 24 hours after treatment. Patients should be informed and receive home antiemetic medication for prevention.
Area of Science:
- Oncology
- Clinical Pharmacology
Background:
- Chemotherapy adverse effects often lack distinction between acute and delayed symptoms.
- Delayed nausea and vomiting (N&V) commence >24 hours post-chemotherapy.
Purpose of the Study:
- To assess the clinical occurrence of chemotherapy-induced delayed nausea and emesis.
- Evaluate delayed N&V in unselected cancer patients.
Main Methods:
- Prospective study of 327 cancer patients across three institutions.
- Patient-reported N&V assessments every 6 hours for 3 days post-chemotherapy.
- No exclusion based on diagnosis, chemotherapy regimen, or antiemetic use.
Main Results:
- One in three patients experienced delayed nausea; one in four experienced delayed emesis.
- Approximately 1 in 6 chemotherapy treatments involved delayed nausea, 1 in 9 involved delayed emesis.
- Delayed N&V are significant clinical concerns.
Conclusions:
- Chemotherapy-induced delayed nausea and vomiting are prevalent and clinically significant.
- Patients receiving outpatient chemotherapy require education and home-based antiemetic prescriptions.
- Proactive management is crucial for preventing delayed N&V side effects.