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Cellular infiltrates in scleroderma skin

R Fleischmajer, J S Perlish, J R Reeves

    Arthritis and Rheumatism
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Cellular infiltrates are common in scleroderma skin biopsies, particularly in localized scleroderma. Their presence and type did not correlate with serum abnormalities in this study.

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    Area of Science:

    • Dermatology
    • Immunology
    • Pathology

    Background:

    • Scleroderma encompasses systemic scleroderma (SS) and localized scleroderma (LS), distinct conditions affecting the skin.
    • Understanding the cellular mechanisms in scleroderma pathogenesis is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate the frequency, distribution, and cellular composition of infiltrates in skin biopsies from SS and LS patients.
    • To explore potential correlations between skin cellular infiltrates and serologic markers.

    Main Methods:

    • Analysis of 108 skin biopsies from patients diagnosed with systemic scleroderma or localized scleroderma.
    • Histopathological examination to identify and characterize cellular infiltrates (e.g., lymphocytes, plasma cells, macrophages).
    • Comparison of findings with available serum serologic data.

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    Main Results:

    • Cellular infiltrates were observed in 49% of systemic scleroderma (SS) cases and 84% of localized scleroderma (LS) cases.
    • Infiltrates were predominantly perivascular or diffuse, composed of lymphocytes, plasma cells, and macrophages.
    • No significant correlation was found between the presence or severity of skin cellular infiltrates and serum serologic abnormalities.

    Conclusions:

    • Cellular infiltrates are a frequent finding in scleroderma skin, with a higher prevalence in localized scleroderma.
    • The specific types of immune cells involved suggest an inflammatory component in the skin lesions.
    • Current serologic markers do not appear to predict the extent or nature of cellular infiltration in the skin of scleroderma patients.