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Alpha s1-casein-specific CD8+ T cell clone that inhibits its own interferon-gamma production by producing
K Nishijima1, T Hisatsune, H Kato
1Department of Applied Biological Chemistry, University of Tokyo, Japan.
Bioscience, Biotechnology, and Biochemistry
|December 1, 1995
Abstract:
A CD8+ T cell clone specific to alpha s1-casein, one of the major allergens in milk, is shown to inhibit its own production of interferon (IFN)-gamma by producing interleukin (IL)-10. Anti-IL-10 antibodies enhanced the production of IFN-gamma induced by the antigen plus antigen-presenting cells from 12 h onward after initiating the culture. This enhancing effect was observed only when the cells were stimulated in the presence of the antigen-presenting cells. Neither IL-2 nor IL-4 abrogated this enhancing effect. This reveals a new regulating mechanism for IFN-gamma production from CD8+ T cells.