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Synthesis and properties of oligonucleotides containing the mutagenic base O4-benzylthymidine
Bioorganic & Medicinal Chemistry
|January 1, 1995
Abstract:
The preparation of synthetic oligodeoxynucleotides containing O4-benzylthymidine (Tbn) is described. The use of standard and t-butylphenoxyacetyl amino protecting groups is compared. The thermal stabilities of duplexes containing Tbn paired with adenine and guanine have been measured.