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Failure of creatine kinase to predict ectopic pregnancy
J Korhonen1, H Alfthan, U H Stenman
1Department of Obstetrics and Gynecology, Helsinki University, Central Hospital, Finland.
Objective:
To investigate serum creatine kinase (CK) levels in pregnant women with ectopic pregnancy (EP), spontaneous abortion, and normal pregnancy with comparable serum hCG concentrations.
Design:
A retrospective, case-controlled study.
Setting:
Helsinki University Central Hospital, Helsinki, Finland.
Patients:
Forty-four patients with a suspicion of EP of which 15 had laparoscopically confirmed tubal pregnancies; 15 had a spontaneous abortion, a blighted ovum, or a missed abortion; and 14 patients a normal intrauterine pregnancy.
Interventions:
The diagnosis was made by transvaginal sonography and serum hCG determinations either at admission or after repeated examinations. Ectopic pregnancy was confirmed and treated by laparoscopy.
Main Outcome Measures:
Serum CK and hCG levels.
Results:
No significant differences in CK levels were observed between the groups by one-way analysis of variance and no correlation was found between serum CK and hCG levels within any group.
Conclusions:
Creatine kinase does not appear to be useful in the diagnosis of early EP.
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