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Tumor necrosis factor-alpha in serum of macaques during SIVmac251 acute infection
P Clayette1, R Le Grand, O Noack
1Laboratoire de Neuropathologie expérimentate et Neurovirologie, CEA/DSV/DPTE/SSA Institut Paris-Sud sur les Cytokines, Fontenay aux Roses, France.
Journal of Medical Primatology
|February 1, 1995
Abstract:
TNF secretion was explored in sera during acute SIV-infection of cynomolgus macaques. A peak of TNF was detected in sera of animals in concomitance with SIV replication. Likewise, AZT treatment delayed and reduced peaks of viral replication and TNF production. Thus, SIVmac251-infected monkey could be an excellent model to explore the interdigitation existing between HIV and TNF in acute and chronic infection and to develop new therapeutic strategies that target the production of this cytokine or its inductive effects.