Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Axonal regeneration

J E Brecknell1, J W Fawcett

  • 1Physiological Laboratory, Cambridge, UK.

Biological Reviews of the Cambridge Philosophical Society
|May 1, 1996
PubMed
Summary

Peripheral nerve injury allows axon regeneration, but central nervous system damage does not. Peripheral nerve grafts can promote central nervous system axon regeneration and behavioral recovery in experimental models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adaptation of tape removal test for measurement of sensitivity in perineal area of rat.

Experimental neurology·2019
Same author

An integrin approach to axon regeneration.

Eye (London, England)·2016
Same author

The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity.

Neural plasticity·2016
Same author

Targeting the neural extracellular matrix in neurological disorders.

Neuroscience·2013
Same author

Use of an implanted sacral nerve stimulator to restore urine voiding in chronically paraplegic dogs.

Journal of veterinary internal medicine·2012
Same author

Chondroitin sulfate: a key molecule in the brain matrix.

The international journal of biochemistry & cell biology·2012

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Peripheral Nerve Injury

Background:

  • Peripheral nerve axons can regenerate after injury, facilitated by Schwann cells, to restore function.
  • Central nervous system (CNS) axonal regeneration is limited in adult mammals, hindering functional recovery.
  • Oligodendrocytes and astrocytes produce inhibitors that impede CNS axonal growth.

Purpose of the Study:

  • To investigate the potential for promoting axonal regeneration in the adult mammalian central nervous system.
  • To explore the use of peripheral nerve grafts as a substrate for CNS axonal growth.
  • To assess the impact of enhanced axonal regeneration on behavioral recovery in experimental models.

Main Methods:

  • Utilizing peripheral nerve grafts as a substrate for central nervous system (CNS) neurons.
  • Experimental models designed to study axonal regeneration after CNS injury.
  • Behavioral assessments to quantify functional recovery post-intervention.

Main Results:

  • Central neurons demonstrated the ability to regenerate axons over long distances when provided with a conducive substrate like a peripheral nerve graft.
  • Experimental models showed a degree of behavioral recovery correlated with successful axonal regeneration.
  • The absence of Schwann cells in the CNS contributes to the lack of natural regeneration.

Conclusions:

  • Peripheral nerve grafts can overcome inhibitory factors in the CNS and support significant axonal regeneration.
  • Promoting CNS axonal regeneration via supportive substrates holds promise for achieving functional recovery after injury.
  • Further research into enhancing regenerative capacity in the CNS is warranted.

Related Experiment Videos