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Regenerative urinary bladder augmentation using small intestinal submucosa: urodynamic and histopathologic assessment
B P Kropp1, M K Rippy, S F Badylak
1Department of Urology, Indiana University Medical Center, Indianapolis, USA.
The Journal of Urology
|June 1, 1996
Summary
Small intestinal submucosa (SIS) shows promise as a bladder augmentation material. Studies indicate SIS acts as a scaffold, promoting bladder tissue regeneration for potential reconstruction.
Area of Science:
- Regenerative Medicine
- Urology
- Biomaterials Science
Background:
- Bladder augmentation is crucial for managing conditions causing bladder dysfunction.
- Tissue engineering offers potential solutions for bladder reconstruction.
- Small intestinal submucosa (SIS) is a biomaterial explored for tissue repair.
Purpose of the Study:
- To assess the efficacy of small intestinal submucosa (SIS) as a material for bladder augmentation.
- To evaluate the regenerative capacity of SIS grafts in partial cystectomy models.
Main Methods:
- Partial cystectomy (35-45%) was performed on 19 male dogs.
- SIS grafts were used for immediate bladder augmentation.
- Pre- and postoperative evaluations included clinical assessments, blood chemistries, urine cultures, and imaging (intravenous urograms, cystograms, cystometrograms).
- Histological and image analyses were conducted 1-15 months postoperatively.
Main Results:
- All dogs completed their intended survival periods without complications.
- Clinical and laboratory results remained within normal ranges.
- Histological examination revealed successful regeneration of all three bladder wall layers (mucosa, smooth muscle, serosa) in SIS-augmented bladders.
Conclusions:
- Small intestinal submucosa serves as an effective scaffold for bladder augmentation.
- SIS facilitates the regeneration of native bladder tissue.
- SIS presents a viable option for future bladder reconstruction strategies.