The pathogenisis of leptospirosis II. Jaundice in experimental leptospirosis in guinea pigs

Different mechanisms responsible for the appearance of jaundice in leptospirosis caused by Leptospira icterohaemorrhagiae in guinea pigs were discussed. Hepatocellular damage was demonstrated with the presence to a lesser extent of intrahepatic biliary obstruction. A massive destruction of extravascular red blood cells liberated by the hemorrhagic diathesis, appeared to be the main cause in the genesis of jaundice. The latter was inhibited following the neutralization of the reticuloendothelial system of guinea pigs by an irradiation before the infection.