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Rheumatoid arthritis. Outcome measures

H E Paulus¹, K J Bulpitt

¹University of California, Los Angeles, UCLA School of Medicine, USA.

Rheumatic Diseases Clinics of North America

|August 1, 1995

Summary

Rheumatologists pioneered outcome measures for drug trials, establishing clinical usefulness. Modern rheumatoid arthritis management relies on these standardized outcome measures for patient care decisions.

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Area of Science:

Clinical Medicine
Rheumatology
Clinical Trials

Background:

Rheumatologists have historically led the development of clinical outcome assessment measures.
Early studies utilized rigorous trial designs and standardized outcome measures to evaluate drug efficacy, particularly for treatments with delayed benefits.

Purpose of the Study:

To highlight the historical significance of outcome measures in rheumatology.
To emphasize the evolution and importance of standardized outcome measures in rheumatoid arthritis (RA) research and clinical practice.

Main Methods:

Review of seminal studies in clinical outcome assessment within rheumatology.
Identification of key historical indices and questionnaires used in RA trials.
Discussion of the progression of outcome measure development since the mid-20th century.

Main Results:

The Lansbury Index (1958) and Empire Rheumatism Gold Trial (1960) demonstrated the utility of double-blind, placebo-controlled designs with standardized outcome measures.
The Health Assessment Questionnaire and Arthritis Impact Measurement Scales emerged in 1980, further advancing RA outcome assessment.
Established outcome measures provide the foundation for evidence-based clinical decision-making in RA management.

Conclusions:

Standardized outcome measures are crucial for evaluating drug efficacy and guiding clinical management in rheumatology.
The ongoing development and application of outcome measures are essential for advancing patient care in rheumatoid arthritis.
Future clinical decision-making paradigms for rheumatoid arthritis will increasingly integrate established outcome measures.

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