Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oncogenes in rheumatoid arthritis

U Müller-Ladner1, J Kriegsmann, R E Gay

  • 1Department of Medicine, University of Alabama at Birmingham 35294-0006, USA.

Rheumatic Diseases Clinics of North America
|August 1, 1995
PubMed
Summary

Rheumatoid arthritis involves aberrant synovial cells driven by an oncogene network. This network, potentially triggered by retroviral particles, explains joint destruction and offers new therapeutic targets.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A lump in the male breast-case report of an unusual tumor manifestation].

Pathologie (Heidelberg, Germany)·2024
Same author

[Massive pancarditis-autopsy report].

Pathologie (Heidelberg, Germany)·2023
Same author

15 years of the histopathological synovitis score, further development and review: A diagnostic score for rheumatology and orthopaedics.

Pathology, research and practice·2017
Same author

[Fifteen years of the histopathological synovitis score : Review and further developments of a diagnostic score].

Zeitschrift fur Rheumatologie·2017
Same author

MALDI IMS and Cancer Tissue Microarrays.

Advances in cancer research·2017
Same author

[Synovial fibroblasts : Main players in rheumatoid arthritis].

Zeitschrift fur Rheumatologie·2016

Area of Science:

  • Molecular Biology
  • Immunology
  • Oncology

Background:

  • Knowledge of oncogenes in cancer impacts understanding of nonmalignant diseases like Rheumatoid Arthritis (RA).
  • Pathohistologic evidence in RA shows transformed synovial cells causing joint destruction, now explained by altered cell regulation and apoptosis.
  • Upregulated oncogenes in RA synovial cells support the hypothesis of aberrant cell invasion.

Purpose of the Study:

  • To explain the role of oncogene interactions in Rheumatoid Arthritis pathogenesis.
  • To propose a modified model of oncogene activation in RA based on new data.
  • To introduce the concept of an 'oncogene network' as a key pathway in RA.

Main Methods:

  • Review and modification of the Carson and Ribero model (1993) for oncogene activation.
  • Inclusion of data on Fas and perforin activity.
  • Consideration of retroviral particles in synovial fluid as a potential stimulus.

Main Results:

  • Synovial cell transformation in RA involves alterations in cell cycle and apoptosis.
  • Co-upregulation of multiple oncogenes may be necessary for transformation.
  • Retroviral particles in synovial fluid are a potential stimulus for oncogene transcription in RA.

Conclusions:

  • An 'oncogene network' acts as a pathogenic mechanism in rheumatoid joint synoviocytes.
  • This oncogene network is proposed as a major T-cell-independent pathway in RA.
  • Understanding oncogene interactions provides new insights into RA pathogenesis.

Related Experiment Videos