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Related Experiment Videos

Reflex sympathetic dystrophy: does sympathetic dysfunction originate from peripheral neuropathy?

H A Kurvers1, L Hofstra, M J Jacobs

  • 1Department of Surgery, Maastricht, The Netherlands.

Surgery
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

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Sympathetic dysfunction in reflex sympathetic dystrophy (RSD) involves altered nerve activity and blood vessel responses. Findings suggest catecholamine hypersensitivity and increased sympathetic nerve impulses in affected limbs.

Area of Science:

  • Neuroscience
  • Vascular Biology
  • Pain Management

Background:

  • Reflex sympathetic dystrophy (RSD) involves sympathetic nervous system dysfunction.
  • Proposed mechanisms include increased sympathetic nerve impulses and catecholamine supersensitivity.
  • The roles of central and peripheral nervous systems in RSD are debated.

Purpose of the Study:

  • To investigate the mechanisms of sympathetic dysfunction in reflex sympathetic dystrophy (RSD).
  • To differentiate between increased sympathetic nerve activity and catecholamine supersensitivity in RSD.
  • To explore the involvement of both proximal and distal aspects of the sympathetic nervous system in RSD.

Main Methods:

  • Assessed sympathetic function in 42 RSD patients using laser Doppler flowmetry for skin blood flow and vasoconstriction.

Related Experiment Videos

  • Utilized ultrasonic vessel wall tracking to measure brachial artery distention and response to cold pressor test.
  • Measured arterial blood pressures with Finapres technique, categorizing patients by limb temperature sensation.

    • Main Results:

    • Distal skin blood flow increased in Stage I and decreased in Stages II/III RSD; vasoconstriction was impaired across all stages.
    • Proximal brachial artery distention and response to cold pressor test were reduced in all RSD stages.
    • No significant differences in pulse pressure were observed between RSD patients and controls.

    Conclusions:

    • Suggests distal sympathetic dysfunction in RSD involves catecholamine hypersensitivity (Stages II/III) secondary to autonomic denervation (Stage I).
    • Indicates potential increases in proximal sympathetic nerve impulses across all RSD stages.
    • Highlights distinct proximal and distal sympathetic alterations in reflex sympathetic dystrophy.