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Acute exposure to carbon monoxide does not affect plasma lipids, lipoproteins, and apolipoproteins
1Department of Medicine, School of Medicine, University of California, Los Angeles, USA.
Study Objectives:
To examine the effects of acute exposure to carbon monoxide and hypoxia on plasma lipids, lipoproteins, and apolipoproteins.
Design:
Random-order assignment to blinded, inhaled exposures of carbon monoxide and hypoxia.
Setting:
Research laboratory of ambulatory subjects.
Subjects:
10 elderly, male nonsmokers with chronic stable angina.
Intervention:
Random-order two-hour inhaled exposure to clean air at sea level, carbon monoxide at sea level, carbon monoxide at high altitude, and clean air at high altitude.
Measurements:
Fasting plasma lipids, lipoproteins, and apolipoproteins before and after exposures.
Results:
No differences were noted between fasting plasma lipid, lipoprotein, or apolipoprotein levels before and after exposures.
Conclusion:
Acute exposure to carbon monoxide and high altitude does not affect fasting plasma lipid, lipoprotein, or apolipoprotein levels.