[The dipeptide L-alanyl-L-glutamine--its preparation and therapeutic use]

L-glutamine, representing one of the principal sources of nitrogen for the organism, can be used in infusion solutions employed in clinical nutrition in the form of the dipeptide L-alanyl-L-glutamine. It can be prepared with the use of biotechnological methods, viz. the enzymic synthesis of the peptide, and fermentation preparation of L-glutamine and the proteases catalyzing the formation of the peptidic bond. Suitable producers of amino acids and enzymes are microorganisms (both bacteria and fungi). The procedures used in the preparation of the components as well as the dipeptide itself are a combination of biotransformations and fermentations.