Related Experiment Videos
Dibefurin, a novel fungal metabolite inhibiting calcineurin phosphatase activity
G M Brill1, U Premachandran, J P Karwowski
1Abbott Laboratories, Abbott Park, Illinois 60064, USA.
The Journal of Antibiotics
|February 1, 1996
Abstract:
The novel calcineurin inhibitor, dibefurin, has been isolated from the fungal culture AB 1650I-759. The isolation was bioactivity-directed fractionation using an assay which measures the phosphatase activity of calcineurin. The compound was purified by countercurrent, reverse phase and gel filtration chromatographies. Several studies, including crystallographic, NMR and MS, revealed that dibefurin is a novel dimeric compound of a unique structural type.