Characterization of haemagglutinating factor produced by mouse spleen and lymph node in culture

Mouse spleen cells produce haemagglutinating activity in culture which is species specific but not strain specific. The activity is produced by all strains of mice tested including nude mice. It is produced in cultures of spleen and lymph node but not of peritoneal exudate cells. Production of the factor is not affected by macrophage depletion of the spleen. This activity is not antibody mediated.