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Characterization of nitrosation products in cosmetics raw materials by liquid chromatography/mass spectrometry
D A Volmer1, J O Lay, M Billedeau
1Food and Drug Administration, National Center for Toxicological Rsearch, Jefferson, AR 72079, USA.
Abstract:
Characterization of nitrosation products in cosmetics raw material samples has been accomplished by three liquid chromatography/mass spectrometry (LC/MS) techniques. Two of the techniques involved conventional methodologies of LC/MS and LC/tandem mass spectrometry, both of which can be used to detect and identify products formed under extreme-nitrosation conditions. The third technique utilized an on-line coupling of a photolysis reactor with the LC/MS, and it may be used as a rapid and specific means of screening for the presence of known and unknown N-nitrosamines, which may be carcinogenic.
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