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Intracranial ependymomas in children: a review of 43 cases

R A Coulon, K Till

    Child'S Brain
    |January 1, 1977
    PubMed

    Insights

    Pediatric intracranial ependymomas showed lower survival rates than expected, possibly due to a high incidence of malignant tumors in this series of 43 children.

    Area of Science:

    • Pediatric neuro-oncology
    • Neurosurgery
    • Pediatric oncology

    Background:

    • Intracranial ependymomas are a significant cause of brain tumors in children.
    • Understanding clinical features and treatment outcomes is crucial for improving pediatric neuro-oncology care.
    • Previous studies highlight the challenges in managing these tumors in young patients.

    Purpose of the Study:

    • To review clinical aspects of intracranial ependymomas in children aged 0-13 years.
    • To analyze treatment modalities including surgery and radiation therapy.
    • To evaluate survival rates and identify factors influencing outcomes.

    Main Methods:

    • Retrospective review of 43 pediatric cases (0-13 years) with intracranial ependymomas.
    • Analysis of clinical data: tumor location, patient age, history duration, symptoms, and skull film findings.
    • Evaluation of treatment approaches: surgical resection, radiation therapy, and biopsy.

    Main Results:

    • 39 patients underwent surgical procedures; 30 received additional radiation therapy.
    • Three patients had needle biopsy only; one died without treatment.
    • Observed survival rates were lower than anticipated, with a notable frequency of malignant tumors.

    Conclusions:

    • The high occurrence of malignant intracranial ependymomas in this pediatric series may explain the suboptimal survival rates.
    • Further research into aggressive tumor biology and tailored treatment strategies is warranted for improved pediatric outcomes.
    • Clinical management of pediatric intracranial ependymomas requires careful consideration of tumor grade and treatment intensity.

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