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Developmental immunohistochemistry of the 22 kDa peroxisomal membrane protein in the human brain
T Miyawaki1, O Sohma, Y Suzuki
1Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
Brain Research
|November 27, 1995
Abstract:
We studied immunohistochemically the 22 kDa peroxisomal membrane protein (PMP 22). In the control brain, the immunopositive neurons for PMP 22 appeared 2-3 weeks earlier than those for peroxisomal enzymes. PMP 22-immunopositive glial cells appeared at 26-27 gestational weeks, increased with gestational age, and were rarely recognized after 1 year of age. In the patients with Zellweger syndrome, PMP 22-immunoreactivity was recognized in neurons, glias, liver and kidney cells.