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Primary ovarian carcinoid tumors

K P Davis1, L K Hartmann, G L Keeney

  • 1Department of Gynecologic Oncology, Presbyterian St. Lukes Medical Center, Colorado 80218,USA.

Gynecologic Oncology
|May 1, 1996
PubMed
Summary

Primary ovarian carcinoid tumors are rare. Early-stage disease confined to the ovary offers an excellent prognosis with surgery alone, while advanced stages have poorer survival outcomes.

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Area of Science:

  • Gynecologic Oncology
  • Pathology
  • Endocrinology

Background:

  • Primary ovarian carcinoid tumors are rare neoplasms.
  • Understanding their histology and clinical behavior is crucial for patient management.

Purpose of the Study:

  • To review the clinical and pathological features of primary ovarian carcinoid tumors.
  • To evaluate the outcomes based on stage and treatment.

Main Methods:

  • Retrospective review of 17 primary ovarian carcinoid tumor cases from Mayo Clinic and Colorado Tumor Registry.
  • Histologic classification and analysis of clinical data, including stage, symptoms, and treatment response.

Main Results:

  • Histologic subtypes included insular (53%), trabecular (29%), and strumal carcinoid (26%).
  • 29% of patients presented with carcinoid syndrome; 41% experienced defecation-related pain.
  • 100% 5-year survival for stage I disease confined to the ovary versus 33% for advanced stages.
  • One patient with suspected stage I disease experienced recurrence 13 years post-diagnosis.

Conclusions:

  • Primary ovarian carcinoid tumors confined to the ovary have an excellent prognosis with surgical management.
  • Advanced stage at diagnosis significantly impacts survival.
  • Systemic chemotherapy showed limited efficacy in advanced cases.

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