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[Polish hydroxyethyl starch preparation: a clinical study]
Acta Haematologica Polonica
|January 1, 1979
Summary
A 6% hydroxyethyl starch (HES) solution was safely administered to surgical patients as a plasma-replacing agent. This HES preparation met all requirements, showing no adverse effects in initial trials.
Area of Science:
- Biochemistry
- Pharmacology
Context:
- The study evaluated a novel 6% hydroxyethyl starch (HES) solution prepared at the Institute of Haematology in Warsaw.
- Surgical patients were the target group for this plasma-replacing agent investigation.
Purpose:
- To assess the safety and efficacy of a specific hydroxyethyl starch (HES) preparation as a plasma volume expander.
- To determine if the HES solution meets the standards for clinical use in surgical patients.
Summary:
- A 6% hydroxyethyl starch (HES) solution with specified molecular weight and molar substitution was infused into surgical patients.
- The HES preparation was found to comply with all requirements for plasma-replacing agents.
- No adverse side effects were observed in any of the patients who received the HES infusion.
Impact:
- The study provides initial evidence for the safe use of this HES preparation in a clinical setting.
- Further research is warranted to investigate the effects of larger volumes of HES in patients with various types of hypovolaemia.