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Renal cell carcinoma in children: the Detroit experience
A L Freedman1, T S Vates, T Stewart
1Department of Pediatric Urology, Children's Hospital of Michigan, Detroit 48201, USA.
Insights
Pediatric renal cell carcinoma often presents at advanced stages. However, children with localized disease or isolated lymph node involvement show promising survival rates, indicating a potentially favorable prognosis.
Area of Science:
- Pediatric Oncology
- Urologic Oncology
Background:
- Renal cell carcinoma (RCC) is rare in children.
- Understanding its presentation and outcomes in pediatric patients is crucial for effective management.
Purpose of the Study:
- To analyze the clinical presentation, treatment strategies, and survival outcomes of pediatric patients diagnosed with renal cell carcinoma.
- To evaluate the prognostic factors influencing survival in this cohort.
Main Methods:
- Retrospective review of medical and pathological records for 6 children diagnosed with RCC between 1980 and 1995.
- Analysis of patient demographics, clinical symptoms, disease stage at diagnosis, treatment received, and follow-up data.
Main Results:
- The most common symptoms were flank pain and abdominal mass (50% each); gross hematuria was infrequent (16%).
- Most patients (5/6) presented with advanced disease (Stage III or IV).
- Patients with Stage III disease showed no recurrence at a mean follow-up of 38.5 months; one Stage IV patient remains disease-free at 22 months.
Conclusions:
- Pediatric renal cell carcinoma frequently presents at advanced stages.
- Prognosis appears encouraging for patients with localized disease or isolated regional lymph node involvement, suggesting potential for successful treatment outcomes.
Purpose:
We analyzed the presentation, treatment and survival of 6 children with renal cell carcinoma.
Materials And Methods:
We retrospectively reviewed the pathological and hospital records of 6 children diagnosed with renal cell carcinoma at Children's Hospital of Michigan (5) and Henry Ford Hospital (1) from 1980 to 1995.
Results:
The most common presenting complaints were flank pain (50%) and a palpable abdominal mass (50%), while gross hematuria was present in only 1 patient (16%). No patient had the classic triad of flank pain, hematuria and palpable mass. Only 1 patient had localized disease (stage II), while 5 of the 6 presented with stage III or IV disease. While followup is limited, all patients with stage III disease are without evidence of recurrence at a mean 38.5 months and 1 of 2 with stage IV disease is without evidence of disease at 22 months.
Conclusions:
Although renal cell carcinoma in childhood often presents at an advanced stage, the prognosis for those with isolated regional lymph node involvement appears to be encouraging.