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Partial spontaneous regression of Bowen's disease
Y Murata1, K Kumano, T Sashikata
1Department of Dermatology, Hyogo Medical Center for Adults, Akashi, Japan.
Archives of Dermatology
|April 1, 1996
Summary
Irregular Bowen's disease lesions, often on the trunk, showed histopathologic signs of regression in normal-appearing skin. These findings suggest partial spontaneous regression may occur in Bowen's disease.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Bowen's disease (squamous cell carcinoma in situ) can present with irregular lesions.
- Previous studies have not investigated the implications of these irregular configurations.
- This study compares patients with irregular lesions to those without.
Purpose of the Study:
- To investigate the clinical features of irregular Bowen's disease lesions.
- To evaluate histopathologic evidence of regression in normal-appearing skin associated with irregular lesions.
Main Methods:
- Compared clinical backgrounds of 34 patients with irregular lesions (group 1) to 56 patients without (group 2).
- Examined lesional, interlesional, and perilesional skin biopsies from 17 group 1 patients.
- Assessed histopathologic features including amyloid deposition, melanophages, vascularity, inflammation, fibrosis, and epidermal atrophy.
Main Results:
- Irregular lesions were more common on the trunk, larger, and longer-lasting.
- Lesional skin showed amyloid deposition, melanophages, increased vascularity, and inflammatory infiltrates.
- Interlesional skin exhibited amyloid deposition, melanophages, increased vascularity, dermal fibrosis, inflammatory infiltrates, and epidermal atrophy.
- Perilesional skin lacked these specific histopathologic findings.
Conclusions:
- Histopathologic findings in normal-appearing interlesional skin suggest regression.
- These findings may indicate partial spontaneous regression of Bowen's disease.