Related Experiment Videos
The GC factor regulates the expression of the insulin-like growth factor-I receptor
A Morrione1, T DeAngelis, R Baserga
1Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Cell Proliferation
|December 1, 1995
Abstract:
We have transfected a plasmid expressing the transcriptional regulator GC Factor (GCF) into cell lines and have found that the GCF: 1 causes a decrease in the levels of insulin-like growth factor I receptor (IGF-IR) mRNA; 2 causes a decrease in the number of IGF-IRs; and 3 represses the activity of the IGF-IR promoter. In addition, we show that the regulation of IGF-IR expression by GCF plays a physiological role in the control of cellular proliferation in vitro.