Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dose-response relationship between urinary cadmium concentration and beta2-microglobulinuria using logistic

M Hayano1, K Nogawa, T Kido

  • 1Department of Hygiene, Chiba University School of Medicine, Inohana, Japan.

Archives of Environmental Health
|March 1, 1996
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bovine quantitative trait loci analysis for growth, carcass, and meat quality traits in an F2 population from a cross between Japanese Black and Limousin.

Journal of animal science·2008
Same author

Quantitative trait loci analysis on Sus scrofa chromosome 7 for meat production, meat quality, and carcass traits within a Duroc purebred population.

Journal of animal science·2008
Same author

Fibroblast Growth Factor May Regulate the Initiation of Oocyte Growth in the Developing Ovary of the Medaka, Oryzias latipes.

Zoological science·2008
Same author

Polymorphisms in the promoter region of the porcine antiviral MX1 and MX2 genes.

Animal genetics·2008
Same author

Combination of the C1429T polymorphism in the G-protein beta-3 subunit gene and the A1330V polymorphism in the low-density lipoprotein receptor-related protein 5 gene is a risk factor for hypercholesterolaemia.

Clinical and experimental medicine·2007
Same author

Concordance between distributed EEG source localization and simultaneous EEG-fMRI studies of epileptic spikes.

NeuroImage·2007

Environmental cadmium exposure is linked to kidney dysfunction in older adults. Higher urinary cadmium levels significantly increase the risk of beta2-microglobulinuria, indicating renal tubular damage.

Area of Science:

  • Environmental Health
  • Toxicology
  • Nephrology

Background:

  • Cadmium is a toxic heavy metal with widespread environmental presence.
  • Chronic exposure to cadmium can lead to renal tubular dysfunction.
  • Understanding dose-response relationships is crucial for public health risk assessment.

Purpose of the Study:

  • To investigate the dose-response relationship between environmental cadmium exposure and renal tubular dysfunction.
  • To assess the influence of age on the association between cadmium exposure and beta2-microglobulinuria.
  • To establish reference urinary cadmium concentrations associated with low prevalence of renal dysfunction.

Main Methods:

  • Logistic regression analysis was employed.
  • Study population included 3178 inhabitants from a cadmium-polluted area and 1134 from a nonpolluted area in Japan, all over 50 years of age.

Related Experiment Videos

  • Urinary cadmium concentration and beta2-microglobulinuria were measured as indicators of exposure and renal tubular dysfunction, respectively.

    • Main Results:

    • Both age and urinary cadmium concentration were significantly associated with beta2-microglobulinuria.
    • A clear dose-response relationship was observed between cadmium levels and the prevalence of renal tubular dysfunction.
    • Calculated urinary cadmium concentrations corresponding to low prevalence rates were 1.6-3.0 µg/g creatinine for men and 2.3-4.6 µg/g creatinine for women.

    Conclusions:

    • Environmental cadmium exposure poses a significant risk for renal tubular dysfunction in older adults.
    • Age is an important factor modifying the risk associated with cadmium exposure.
    • The study provides age- and sex-specific reference values for urinary cadmium concentration to aid in health risk assessment.