Related Experiment Videos
[Change in argatroban concentration within the vessel wall after local administration using hydrogel-coated balloon
T Imanishi1, M Arita, K Shiizaki
1Department of Cardiology, Wakayama Medical College, Japan.
Insights
This study shows hydrogel-coated balloons effectively deliver argatroban to the arterial wall during angioplasty. This method ensures localized drug delivery, potentially reducing complications like acute coronary occlusion.
Area of Science:
- Cardiovascular Medicine
- Biomaterials Science
- Interventional Cardiology
Background:
- Acute coronary occlusion is a significant risk following percutaneous transluminal coronary angioplasty.
- Effective local drug delivery to the arterial wall remains a challenge in coronary interventions.
Purpose of the Study:
- To evaluate the efficacy of a hydrogel-coated balloon for delivering argatroban to the arterial wall.
- To assess the persistence of argatroban in the arterial wall after angioplasty.
Main Methods:
- A hydrogel-coated balloon catheter was used to deliver argatroban to the common carotid artery in 17 rabbits.
- The balloon was immersed in an argatroban/saline solution and inflated within the artery.
- Argatroban concentrations in the arterial wall were measured using high-performance liquid chromatography at various time points post-inflation.
Main Results:
- The hydrogel-coated balloon successfully transferred argatroban to the vascular wall.
- Argatroban concentrations in the arterial wall were measured at 14.8 nmole/g.wet weight immediately after deflation, decreasing to 4.2 nmole/g.wet weight at 5 minutes and 3.9 nmole/g.wet weight at 15 minutes.
Conclusions:
- Hydrogel-coated balloon technology enables localized delivery of argatroban to the arterial wall during angioplasty.
- This approach holds promise for mitigating acute coronary occlusion and improving outcomes in coronary interventions.
Abstract:
Acute coronary occlusion after percutaneous transluminal coronary angioplasty is one of the major problems in coronary intervention. This study evaluated the hydrogel-coated balloon delivery of argatroban to the arterial wall and argatroban persistence after angioplasty in 17 rabbits. A hydrogel-coated balloon was immersed three times in argatroban/saline solution (1 mg/ml) and inflated at 6 atm pressure for 1 min in the common carotid artery. The transfer of argatroban to the vascular wall was measured by high-performance liquid chromatography. The concentrations of argatroban at 0, 5, and 15 min after deflation were 14.8, 4.2, and 3.9 nmole/g.wet weight. The hydrogel-coated balloon catheter can deliver argatroban to the local arterial wall during balloon inflation.