Related Experiment Video

Updated: Aug 9, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

[Temporary results only in electroconvulsive therapy in therapy-resistant depression; retrospective study]

A Lemstra1, A F Leentjens, W W van den Broek

  • 1Academisch Ziekenhuis Rotterdam-Dijkzigt, afd. Psychiatrie.

Nederlands Tijdschrift Voor Geneeskunde
|February 3, 1996
PubMed
Summary

Electroconvulsive therapy (ECT) effectively treats acute major depression. However, relapse rates are high within a year, suggesting limited long-term efficacy for this depression treatment.

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Electroconvulsive Therapy01:30

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...