Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary orbital melanomas

M Tellada1, C S Specht, I W McLean

  • 1Department of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.

Ophthalmology
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transpupillary collagen photocrosslinking for targeted modulation of ocular biomechanics.

Biomaterials·2021
Same author

Analysis of Damage and Wound Healing in the Retinal Pigmented Epithelium.

Advances in experimental medicine and biology·2019
Same author

[Lymphoma of Ocular and Periocular Tissues - Clinicopathological Correlations].

Klinische Monatsblatter fur Augenheilkunde·2016
Same author

Sustained reduction of intraocular pressure by supraciliary delivery of brimonidine-loaded poly(lactic acid) microspheres for the treatment of glaucoma.

Journal of controlled release : official journal of the Controlled Release Society·2016
Same author

[Clinico-pathological correlations: posterior compartment of the eye and orbit].

Klinische Monatsblatter fur Augenheilkunde·2012
Same author

Inflammatory cellular kinetics in sympathetic ophthalmia a study of 29 traumatized (exciting) eyes.

Ocular immunology and inflammation·2012
Same journal

Metastasis of Nasopharyngeal Squamous Cell Carcinoma to the Angle.

Ophthalmology·2026
Same journal

Endocrine Mucin-Producing Sweat Gland Carcinoma of Eyelid.

Ophthalmology·2026
Same journal

Multimodal Imaging of Optic Nerve Invasion in Unilateral Retinoblastoma.

Ophthalmology·2026
Same journal

Avacincaptad Pegol Slows Progressive Ellipsoid Zone Degradation/Loss in Eyes With Geographic Atrophy.

Ophthalmology·2026
Same journal

Access to Intravitreal Anti-VEGF Drugs in Persons with Medicare Advantage Compared with Medicare Fee-For-Service.

Ophthalmology·2026
Same journal

Re: Dones et al.: Emergency department use of ocular point-of-care ultrasound and its utility in diagnosis at a tertiary academic medical center (Ophthalmology. 2026;133:720-727).

Ophthalmology·2026
See all related articles

Primary orbital melanomas, often linked to blue nevi, share prognostic indicators with uveal melanomas. Histopathologic features like cell type and mitotic count predict outcomes in these rare eye tumors.

Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Primary orbital melanomas are rare malignancies with unclear biological behavior.
  • Existing data primarily consists of isolated case reports.
  • Prognostic indicators for uveal melanomas are well-established but their applicability to orbital melanomas requires evaluation.

Purpose of the Study:

  • To assess the utility of histopathologic prognostic indicators used for uveal melanomas in primary orbital melanomas.
  • To correlate histopathologic findings with clinical outcomes in a series of primary orbital melanomas.

Main Methods:

  • Retrospective analysis of 21 primary orbital melanomas with at least one year of follow-up.
  • Evaluation of modified Callender cell type, mitotic count, lymphocyte count, presence of a blue nevus component, and largest tumor diameter.

Related Experiment Videos

  • Clinical follow-up data including mortality from metastatic disease was collected.

    • Main Results:

    • The study included 21 patients, predominantly white, with a mean age of 42 years.
    • Ninety percent of cases had an associated blue nevus, and 47.5% had congenital melanosis.
    • Mortality from metastatic disease occurred in 38% of patients, with liver and brain metastases observed. Poor prognostic indicators included mixed cell type, high mitotic count, and older age with congenital melanosis.

    Conclusions:

    • Primary orbital melanomas frequently occur in white patients and are associated with blue nevi.
    • Prognostic indicators for orbital melanomas appear similar to those for uveal melanomas.
    • The metastatic pattern of primary orbital melanomas mirrors that of uveal melanomas.