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Decrease in muscle glutamine, ribosomes, and the nitrogen losses are similar after laparoscopic compared with open
F Hammarqvist1, B Westman, C E Leijonmarck
1Department of Surgery, Clinical Research Laboratory, St. Göran's Hospital, Stockholm, Sweden.
Surgery
|April 1, 1996
Summary
Laparoscopic cholecystectomy causes a similar stress response affecting muscle amino acid and protein metabolism as open surgery. Postoperative muscle changes and nitrogen balance are comparable between both surgical approaches.
Area of Science:
- Surgical Metabolism
- Protein Synthesis
- Minimally Invasive Surgery
Background:
- Cholecystectomy is a common surgical procedure.
- Laparoscopic cholecystectomy is increasingly preferred over open surgery.
- Understanding the metabolic impact of different surgical approaches is crucial.
Purpose of the Study:
- To compare postoperative muscle amino acid patterns.
- To evaluate ribosome concentration and size distribution in muscle.
- To assess nitrogen balance after laparoscopic versus open cholecystectomy.
Main Methods:
- Studied patients undergoing laparoscopic (LAP) or open (OPEN) cholecystectomy (n=8 each).
- Measured muscle amino acids, ribosomes, and polyribosomes preoperatively and on postoperative day 2.
- Determined cumulative nitrogen balance.
Main Results:
- Observed significant decreases in muscle glutamine and polyribosomes in both groups.
- No significant differences in muscle glutamine or polyribosome reduction between LAP and OPEN groups.
- Similar cumulative nitrogen losses were found in both the LAP and OPEN groups.
Conclusions:
- Laparoscopic cholecystectomy elicits a stress response impacting muscle metabolism.
- The magnitude of this stress response is similar to open cholecystectomy.
- Postoperative muscle changes and nitrogen balance are comparable between the two surgical methods.