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Controlling IGF-receptor function: a possible strategy for tumor therapy

R Baserga1

  • 1Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. baserga1@jeflin.rju.edu

Trends in Biotechnology
|May 1, 1996
PubMed

The insulin-like growth factor-1 receptor (IGF-IR) is one of several growth-factor receptors that regulate the proliferation of mammalian cells. However, its ubiquitousness and certain unique aspects of its function make IGF-IR an ideal target for therapeutic interventions against abnormal growth, with very little effect on normal cells.

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