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Related Experiment Videos

A simple method to predict whether topical agents will interfere with phototherapy

C Kornreich1, Z S Zheng, G Z Xue

  • 1Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Cutis
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

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Many topical psoriasis treatments interfere with phototherapy. Salicylic acid, tar, calcipotriene, anthralin, and tretinoin preparations absorb ultraviolet light and should be removed before or applied after treatment.

Area of Science:

  • Dermatology
  • Photobiology
  • Pharmaceutics

Background:

  • Phototherapy is a common treatment for psoriasis.
  • Topical agents are frequently used concurrently with phototherapy.
  • Potential interactions between topical agents and ultraviolet (UV) light are not fully understood.

Observation:

  • Twenty-one topical psoriasis agents were tested for UV absorbance.
  • Extractions were made using ethanol, hexanes, and 1,4-dioxane.
  • Absorbance was measured between 260-400 nm to assess interference with UVB and UVA phototherapy.

Findings:

  • Salicylic acid preparations strongly absorb UVB.
  • Tar-based products absorb both UVA and UVB.
  • Calcipotriene, anthralin, and tretinoin also showed significant UV absorbance.

Related Experiment Videos

  • Topical steroids and ammonium lactate had minimal UV absorbance.

    • Implications:

    • Certain topical agents can interfere with phototherapy efficacy by absorbing UV light.
    • Salicylic acid, tar, calcipotriene, anthralin, and tretinoin should be removed before or applied after phototherapy sessions.
    • This research aids in optimizing psoriasis phototherapy by guiding topical agent application timing.