Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clostridium difficile colitis in the critically ill

S Grundfest-Broniatowski1, M Quader, F Alexander

  • 1Department of General Surgery, Cleveland Clinic Foundation, Ohio 44195, USA.

Diseases of the Colon and Rectum
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long term assessment of antibiotic prophylaxis and biliary microbiome in pancreaticoduodenectomy.

HPB : the official journal of the International Hepato Pancreato Biliary Association·2022
Same author

Changing trends in surgery for abdominal Crohn's disease.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2018
Same author

Evaluation of radiation-related invasion in primary patient-derived glioma cells and validation with established cell lines: impact of different radiation qualities with differing LET.

Journal of neuro-oncology·2018
Same author

What is the fate of the cholecystostomy tube following percutaneous cholecystostomy?

Surgical endoscopy·2016
Same author

Two randomized, double-blind, placebo-controlled, dose-escalation phase 1 studies evaluating BTH1677, a 1, 3-1,6 beta glucan pathogen associated molecular pattern, in healthy volunteer subjects.

Investigational new drugs·2016
Same author

Local weighting of nanometric track structure properties in macroscopic voxel geometries for particle beam treatment planning.

Physics in medicine and biology·2015
Same journal

A Penny for Your Thoughts.

Diseases of the colon and rectum·2026
Same journal

June 2026 Translations.

Diseases of the colon and rectum·2026
Same journal

Selected Abstracts.

Diseases of the colon and rectum·2026
Same journal

Recurrence After Rectopexy: Insights From Magnetic Resonance Defecography.

Diseases of the colon and rectum·2026
Same journal

Risk of Metabolic Disease After Right- vs Left-Sided Colectomy for Colon Cancer: A Nationwide Cohort Study.

Diseases of the colon and rectum·2026
Same journal

Sexual Distress Is Common in Long Term Follow-up After Pelvic Pouch for Ulcerative Colitis: A Cross-Sectional Study.

Diseases of the colon and rectum·2026
See all related articles

Clostridium difficile colitis (CDC) in critically ill patients often requires surgery, with total colectomy and diversion showing better outcomes than diversion alone. This study evaluated treatment and outcomes in intensive care unit patients with CDC.

Area of Science:

  • Critical Care Medicine
  • Gastroenterology
  • Infectious Diseases

Background:

  • Clostridium difficile colitis (CDC) morbidity and treatment remain subjects of debate, with varying claims on severity.
  • Patient population differences and bacterial virulence may influence observed morbidity in CDC.

Purpose of the Study:

  • To evaluate the impact and treatment outcomes of Clostridium difficile colitis (CDC) in critically ill patients.
  • To compare the effectiveness of different surgical interventions for severe CDC.

Main Methods:

  • Retrospective review of 59 intensive care unit (ICU) patients diagnosed with CDC between January 1991 and October 1994.
  • Analysis of patient symptoms, signs, antibiotic regimens, diagnostic methods, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, morbidity, and mortality.

Related Experiment Videos

  • Comparison of surgical treatment results with existing literature.

    • Main Results:

    • The study included 59 ICU patients with CDC, with a mean age of 66.4 years.
    • Medical treatments included metronidazole and vancomycin; 20.3% of patients required surgery for progressive toxicity or peritonitis.
    • Surgical patients had significantly higher APACHE II scores (24.4 vs. 19.9) and a 30-day mortality of 41.7% compared to 14.7% in medically treated patients.

    Conclusions:

    • Approximately 20% of critically ill patients with CDC necessitated surgical intervention.
    • Total colectomy with diversion demonstrated superior efficacy compared to diversion alone for surgical management of CDC.