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Symptomatology and growth in infants with cow's milk protein intolerance using two different whey-protein hydrolysate
J J Verwimp1, J G Bindels, M Barents
1Nutricia Research, Zoetermeer, The Netherlands.
Insights
Whey-hydrolysate formulas effectively manage cow's milk protein intolerance in infants, improving allergic symptoms and supporting normal growth. Both tested formulas demonstrated comparable efficacy in this primary healthcare setting study.
Area of Science:
- Pediatrics
- Allergology
- Clinical Nutrition
Background:
- Cow's milk protein intolerance (CMPI) is a common condition in infants.
- Standardized diagnostic and treatment approaches are crucial in primary healthcare settings.
Purpose of the Study:
- To compare the efficacy of two whey-hydrolysate based infant formulas (Nutrilon Pept and Pepti Junior) in managing allergic symptoms and supporting growth in infants with CMPI.
- To evaluate the impact of differing fat sources (MCT vs. LCT) and lactose content on infant outcomes.
Main Methods:
- A study involving 79 infants (≤3 months old) diagnosed with CMPI via elimination/provocation.
- Infants were treated with either Nutrilon Pept or Pepti Junior for at least 10 weeks.
- Growth and symptomatology (skin, respiratory, gastrointestinal) were monitored.
Main Results:
- Both formulas supported normal infant growth.
- Over 80% of infants showed improvement in overall allergic symptoms.
- Significant reductions in eczema and infantile colic were observed.
- No significant differences in efficacy were found between the two formulas.
Conclusions:
- Exclusive use of either whey-hydrolysate formula improved allergic symptoms and supported normal growth in infants with CMPI.
- The specific fat composition or lactose presence did not appear to influence the overall efficacy in this study.
- Whey-hydrolysate formulas are effective interventions for CMPI in primary healthcare.
Abstract:
Both growth and the course of allergic symptoms were evaluated in 79 infants with cow's milk protein intolerance, aged three months or younger, diagnosed by standard elimination/provocation and treated with a whey-hydrolysate based infant formula: Nutrilon Pept or Pepti Junior. The efficacy of both products, in terms of symptomatology and growth, was compared with each other. The products differ in fat source (Pepti Junior 50% of its fat as MCT, Nutrilon Pepti normal LCT fat blend) and the presence of lactose (Pepti Junior: lactose free; Nutrilon Pepti: 40% of its carbohydrate as lactose). The study was part of a large project that aimed at standardising the approach towards cow's milk protein intolerance in Baby Health Clinics. Nearly 50 Baby Health Clinics participated in this project. In this study, growth and symptomatology (skin, respiratory tract, gastrointestinal tract) were monitored during an intervention period of at least 10 weeks. Infants in both feeding groups showed normal growth, and in at least 80% of the infants an improvement of the overall symptomatology could be seen during the intervention period. Most profound were the decreases in prevalence and severity of eczema and infantile colic. No differences in efficacy were found in this study between the two infant formulas. It was concluded that the exclusive use of either whey hydrolysate based infant formula resulted in an improvement of allergic symptoms and in normal growth in infants diagnosed by elimination/provocation for cow's milk protein intolerance in a Primary Health Care setting.