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Experimental study of combined hyperthermic and photodynamic therapy on carcinoma in the mouse
1Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan.
Abstract
Purpose:
This study investigates the cytotoxic effect of photodynamic therapy using high-power laser irradiation on cancer cells.
Materials And Methods:
High- or low-power irradiation from a pulsed Nd:YAG dye laser with or without a photosensitizer was administered to an NR-S1 carcinoma in the mouse dorsum.
Results:
Photodynamic therapy with high-power laser irradiation yielded better results than conventional photodynamic therapy or hyperthermia with high-power laser irradiation.
Conclusion:
Photodynamic therapy with high-power laser irradiation is more effective because it generates both a hyperthermic and a photodynamic effect.