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The effect of pregnancy on the growth of primary methylcholanthrene sarcoma isografts
Primary isografts of a highly immunogenic methylcholanthrene tumor were injected into pregnant C57/BL mice. Tumor growth was studied and compared to isografts injected into virgin C57/BL mice preimmunized with fetal antigens. Significant in vivo enhancement of MCA tumor growth was noted in both intra-and interstrain pregnant mice compared with virgin controls. In addition, active preimmunization of virgin mice with hybrid fetal liver did not result in rejection of primary tumor isografts, suggesting that fetal antigens did not contribute to the immunogenicity of this MCA tumor.
Primary isografts of a highly immunogenic methylcholanthrene tumor were injected into pregnant C57/BL mice. Tumor growth was studied and compared to isografts injected into virgin C57/BL mice preimmunized with fetal antigens. Significant in vivo enhancement of MCA tumor growth was noted in both intra-and interstrain pregnant mice compared with virgin controls. In addition, active preimmunization of virgin mice with hybrid fetal liver did not result in rejection of primary tumor isografts, suggesting that fetal antigens did not contribute to the immunogenicity of this MCA tumor.