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[Herpes simplex infection in newborn infants]
Akusherstvo I Ginekologiia
|January 1, 1995
Summary
Neonatal herpes simplex virus infection presents diverse clinical forms, impacting multisystem organs or the central nervous system. Despite treatment, significant mortality and long-term sequelae remain a concern in affected newborns.
Area of Science:
- Virology
- Neonatology
- Infectious Diseases
Context:
- Herpes simplex virus (HSV) infection in newborns is a serious condition.
- Maternal history of HSV shedding is not always evident.
- Clinical presentation varies, affecting multiple organs or the central nervous system.
Purpose:
- To report on six cases of neonatal herpes simplex virus infection.
- To describe the clinical manifestations and outcomes.
- To evaluate the effectiveness of antiviral treatments.
Summary:
- Six neonates with confirmed herpes simplex virus infection were studied.
- Three infants presented with multisystem disease, and three with central nervous system involvement.
- Despite antiviral therapy (Herpesbulin, Pandavir, Zovirax), one infant died from meningoencephalitis, and three of the five survivors developed late sequelae.
Impact:
- Highlights the severe potential of neonatal herpes simplex virus infection.
- Underscores the challenges in diagnosis and management, even with negative maternal history.
- Emphasizes the need for continued research into effective treatments and prevention strategies for neonatal herpes.