Related Experiment Videos
[Thrombosis-resistant heparin-coated diffusion membrane oxygenators: an experimental study]
T Tkebuchava1, L K von Segesser, B Leskosek
1Klinik für Herzgefässchirurgie, Universitätsspital Zürich.
Swiss Surgery. Supplement
|January 1, 1996
Summary
Heparin-coated cardiopulmonary bypass circuits demonstrate effective thromboresistance with reduced systemic heparinization. This approach maintains stable blood parameters and is suitable for long-term perfusions.
Area of Science:
- Biomaterials Science
- Cardiovascular Surgery
- Hematology
Context:
- Cardiopulmonary bypass (CPB) requires anticoagulation to prevent circuit thrombosis.
- Heparin coating of CPB components aims to reduce systemic heparin requirements.
- Investigating the thromboresistance of heparin-coated systems is crucial for patient safety.
Purpose:
- To evaluate the thromboresistance of heparin-coated diffusion membrane oxygenators and associated components.
- To assess the efficacy of reduced systemic heparinization during CPB.
- To monitor key hemostatic parameters throughout a six-hour perfusion in a bovine model.
Summary:
- A bovine model using heparin-coated CPB circuits with reduced systemic heparin (100 IE/kg) was studied for six hours.
- Activated clotting time remained elevated (>180s), and antithrombin III levels showed a significant decrease.
- Platelet count, fibrinogen, and fibrinopeptide A remained stable, with no mechanical defects or plasma leakage observed.
Impact:
- The heparin-coated bypass circuit with reduced systemic heparinization shows promise for long-term CPB procedures.
- This strategy may minimize complications associated with high systemic heparin doses.
- Further research can explore clinical applications of this optimized anticoagulation approach.