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[Self-expanding endoluminal vascular prosthesis: experimental basis and in-vivo evaluation]
B Marty1, T Marty, L K von Segesser
1Klinik für Herz- und Gefässchirurgie, Universitätsspital Zürich.
Swiss Surgery. Supplement
|January 1, 1996
Summary
This study evaluated a self-expandable Wallstent with polyurethane sealant. The covered stent demonstrated 100% patency in minipigs, meeting endovascular prosthesis requirements for treating vascular defects.
Area of Science:
- Biomaterials Science
- Medical Device Engineering
- Vascular Surgery
Background:
- Current endovascular prostheses face challenges with sealing and patency.
- Microporous polyurethane sealants offer potential for improved stent performance.
- Assessing physical properties and in vivo application is crucial for novel stent development.
Purpose of the Study:
- To investigate the physical properties of a self-expandable Wallstent with an incorporated microporous polyurethane sealant.
- To evaluate the in vivo application and performance of this novel covered stent in a preclinical model.
Main Methods:
- Physical characterization: Measurement of diameter, length, and axial load to calculate radial pressure.
- Porosity assessment: Comparison with non-gelatin-sealed knitted Dacron grafts.
- In vivo study: Implantation of 11 covered stents (11.5F catheter) into the aorta of three minipigs.
- Evaluation methods: Pressure measurement and angiography.
Main Results:
- Stent coverage increased radial pressure by 0.05-0.1 bar.
- Calculated pressure-diameter relationship was established.
- Porosity was comparable to Dacron grafts.
- Achieved a 100% patency rate in the minipig model.
Conclusions:
- The covered Wallstent exhibits physical properties suitable for endovascular prostheses.
- The stent's characteristics suggest potential for excluding fistulas and small aneurysms.
- Further research is warranted to explore clinical applications.