Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Thrombosis-resistant heparin-coated diffusion membrane oxygenators: an experimental study]

T Tkebuchava1, L K von Segesser, B Leskosek

  • 1Klinik für Herzgefässchirurgie, Universitätsspital Zürich.

Swiss Surgery. Supplement
|January 1, 1996
PubMed
Summary

Heparin-coated cardiopulmonary bypass circuits demonstrate effective thromboresistance with reduced systemic heparinization. This approach maintains stable blood parameters and is suitable for long-term perfusions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How to prevent venous cannula orifice obstruction during extracorporeal circulation.

Perfusion·2014
Same author

Risk factors for HR- and HER2-defined breast cancer in Slovenian postmenopausal women.

Climacteric : the journal of the International Menopause Society·2011
Same author

Hormone replacement therapy and some risk factors for breast cancer among Slovenian postmenopausal women.

Climacteric : the journal of the International Menopause Society·2011
Same author

Effects of different types of exercise training followed by detraining on endothelium-dependent dilation in patients with recent myocardial infarction.

Circulation·2009
Same author

Atrial assist device, a new alternative to lifelong anticoagulation?

Swiss medical weekly·2009
Same author

A simple way to decompress the left ventricle during venoarterial bypass.

The Thoracic and cardiovascular surgeon·2008

Area of Science:

  • Biomaterials Science
  • Cardiovascular Surgery
  • Hematology

Context:

  • Cardiopulmonary bypass (CPB) requires anticoagulation to prevent circuit thrombosis.
  • Heparin coating of CPB components aims to reduce systemic heparin requirements.
  • Investigating the thromboresistance of heparin-coated systems is crucial for patient safety.

Purpose:

  • To evaluate the thromboresistance of heparin-coated diffusion membrane oxygenators and associated components.
  • To assess the efficacy of reduced systemic heparinization during CPB.
  • To monitor key hemostatic parameters throughout a six-hour perfusion in a bovine model.

Summary:

  • A bovine model using heparin-coated CPB circuits with reduced systemic heparin (100 IE/kg) was studied for six hours.

Related Experiment Videos

  • Activated clotting time remained elevated (>180s), and antithrombin III levels showed a significant decrease.
  • Platelet count, fibrinogen, and fibrinopeptide A remained stable, with no mechanical defects or plasma leakage observed.

    • Impact:

    • The heparin-coated bypass circuit with reduced systemic heparinization shows promise for long-term CPB procedures.
    • This strategy may minimize complications associated with high systemic heparin doses.
    • Further research can explore clinical applications of this optimized anticoagulation approach.