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Gastric carcinoma in siblings with Friedreich's ataxia
R Ackroyd1, A J Shorthouse, T J Stephenson
1Department of Surgery, Royal Hallamshire Hospital, Sheffield, UK.
Abstract:
Friedreich's ataxia is a hereditary neurological condition characterized by severe ataxia. We report the cases of two siblings with this condition, both of whom developed signet ring cell adenocarcinoma of the stomach at a young age. This association has not been previously described and it suggests the presence of an unidentified aberrant gene.