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Tamoxifen-induced growth of leiomyomas. A case report
1Department of Obstetrics and Gynecology, College of Physicians and Surgeons of Columbia University, New York, New York, USA.
The Journal of Reproductive Medicine
|February 1, 1996
Abstract
Background:
Tamoxifen, a nonsteroidal estrogen agonist-antagonist, is used in the treatment of breast cancer.
Case:
A postmenopausal woman, aged 73, while being treated with Tamoxifen, developed continuous growth of her myomatous uterus, became symptomatic and required surgery.
Conclusion:
Tamoxifen at a dose of 40 mg/d has been associated with endometrial carcinoma. The growth of myomas seen with Tamoxifen in this patient seems to be a result of its direct agonist properties.