[Strategies for studies on mechanism of action of antineoplastic agents]

A concise review of the progress in strategies of anticancer drug screening methods provides a background for showing the selected examples of the results from our studies in the field of experimental antitumor therapy. The antineoplastic activity of ifosfamide bromoanalogues is presented in comparison with clinically used cytostatic drugs from the same chemical group. The results obtained by combined chemo-immunotherapy with exploitation of mIL-2 gene transfected plasmacytoma cells (X-63-mIL-2) applied in tumor-bearing mice exemplifies one of the novel approaches in anticancer treatment.