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Increased bactericidal activity as documented by serum bactericidal titers for a triple combination of cell wall
S J Antony1, P Matherin, C Stratton
1Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Abstract:
Infections caused by entercocci have become increasingly difficult to treat because these bacteria are becoming increasingly resistant to commonly used antibiotics such as ampicillin, gentamicin and vancomycin. A consensus for an optimal therapy of enterococcal infections caused by resistant isolates has not yet been determined. We present a patient with prolonged enterococcal sepsis in whom a combination of ampicillin, vancomycin and imipenem was ultimately successful in suppressing enterococcal bacteremia. The enhanced activity of this triple combination was documented by the results of serial serum bactericidal titers.