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[Desmoids: are there any new developments?]

A Sevcík1, F Antos, M Baader

  • 1Chirurgická klinika FN Bulovka.

Rozhledy V Chirurgii : Mesicnik Ceskoslovenske Chirurgicke Spolecnosti
|September 1, 1995
PubMed
Summary
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Mesenteric desmoids present complex therapeutic challenges. Current treatments including chemotherapy, hormonal therapy, and surgery show limited success, with high relapse rates and no standardized approach.

Area of Science:

  • Oncology
  • Surgical Oncology

Background:

  • Mesenteric desmoids are rare, locally aggressive fibrotic tumors.
  • Evaluating current therapeutic options for mesenteric desmoids is crucial due to their challenging nature.

Observation:

  • The review details cytotoxic and non-cytotoxic chemotherapy, actinotherapy, and hormonal therapy.
  • Surgical resection is feasible for smaller tumors (<15 cm) but limited by size and early detection.
  • Conservative management combining non-cytotoxic and hormonal treatments is preferred for larger tumors.

Findings:

  • Actinotherapy is not suitable for intra-abdominal desmoids.
  • High relapse rates are observed, and a standard therapeutic protocol is lacking.
  • Overall treatment outcomes are not encouraging, despite occasional spontaneous remissions.

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Implications:

  • Further research is needed to develop effective and standardized treatments for mesenteric desmoids.
  • Improved diagnostic and therapeutic strategies are required to enhance patient outcomes.
  • The case history highlights the difficulties encountered even with aggressive treatment approaches.