Related Experiment Videos
Lipid peroxidation, antioxidant defences and red-cell membrane changes in relation to coronary risk index and
K R Shanmugasundaram1, K Srinivas, P Sundaram
1Department of Biochemistry, University of Madras, Taramani, India.
Insights
This study establishes normal lipoprotein profiles and identifies early warning signs for coronary heart disease (CHD). Higher levels of certain lipids and lower antioxidant defenses in healthy individuals indicate increased CHD risk.
Area of Science:
- Cardiovascular Science
- Biochemistry
- Lipidology
Background:
- Establishing normal lipoprotein profiles is crucial for identifying cardiovascular disease risk factors.
- Early detection of coronary heart disease (CHD) relies on understanding deviations from normal physiological parameters.
Purpose of the Study:
- To define the typical lipoprotein profile in the general population.
- To pinpoint early indicators of coronary heart disease (CHD).
Main Methods:
- Conducted random blood sampling in healthy adults and patients with symptomatic CHD, including acute myocardial infarction.
- Assayed plasma lipids, lipoproteins, lipid peroxidation, antioxidant enzymes, and red-cell membrane components.
Main Results:
- Established normal ranges for plasma lipids and lipoproteins.
- Identified significantly higher levels of free fatty acids, fibrinogen, white blood cells, echinocytes, and specific red-cell membrane components in individuals with a high coronary risk index.
- Observed significantly lower antioxidant defenses in symptomatic CHD patients.
Conclusions:
- Antioxidant defenses play a key role in controlling lipid peroxidation and distinguishing healthy individuals from those at risk.
- Lowered antioxidant capacity is a significant factor in symptomatic coronary heart disease.
Objective:
To establish the normal lipoprotein profile in the population and identify the early warning signs of coronary heart disease (CHD).
Design:
Random blood sampling of healthy adults and patients with symptomatic CHD including that complicated with acute myocardial infarction.
Methods:
Plasma lipids, lipoproteins, lipid peroxidation, antioxidant enzymes and scavengers, red-cell membrane lipids and glycoproteins were assayed.
Results And Conclusion:
The normal levels of plasma lipids and lipoproteins were established. Levels of plasma free fatty acids, fibrinogen, white blood cell counts, echinocytes, red-cell membrane lipids and protein-bound carbohydrate components are significantly higher in healthy subjects with coronary risk index above 4.5 than they are in normal individuals. Antioxidant defences appear to be the distinguishing factor, remaining higher in normal individuals and thus keeping lipid peroxidation under control. In symptomatic CHD, antioxidant defences are significantly lowered.