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The human SOX11 gene: cloning, chromosomal assignment and tissue expression
1Centre de Recherches de Biochimie Macromoléculaire, CNRS UPR 9008, INSERM U.249, Montpellier, France.
Genomics
|September 20, 1995
Summary
The human SOX11 gene, related to the SRY gene, was cloned and mapped to chromosome 1p25. Its conserved sequence and expression suggest SOX11 is crucial for nervous system development.
Area of Science:
- Genetics
- Molecular Biology
- Neuroscience
Background:
- The SRY (sex-determining region Y) gene contains an HMG box DNA binding motif.
- SOX (SRY-box) genes are a family related to SRY.
- SOX11 is a gene within this family.
Purpose of the Study:
- To clone and characterize the human SOX11 gene.
- To determine the chromosomal location of SOX11.
- To investigate the potential role of SOX11 in the developing nervous system.
Main Methods:
- Partial cloning of human and mouse SOX11 genes.
- DNA sequence analysis.
- Chromosomal mapping.
- Comparative sequence analysis with chicken homologue.
- Analysis of transcriptional domains.
- Expression pattern analysis.
Main Results:
- The human SOX11 gene was successfully cloned and characterized.
- SOX11 was mapped to chromosome 1p25.
- The SOX11 sequence shows strong conservation with its chicken homologue and is related to SOX4.
- SOX11 possesses putative transcriptional activator or repressor domains.
- The expression pattern of SOX11 supports its role in neural development.
Conclusions:
- SOX11 is a conserved gene with potential regulatory functions.
- The chromosomal location of SOX11 is 1p25.
- SOX11 plays a significant role in the developing nervous system.