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Technetium-99m-MIBI scintigraphy in pulmonary tuberculosis
C Onsel1, K Sönmezoglu, G Camsari
1Nuclear Medicine Department, Cerrahpasa Medical Faculty, Istanbul, Turkey.
Summary
99mTc-methoxyisobutylisonitrile (MIBI) scintigraphy shows high uptake in active pulmonary tuberculosis (PTB) granulomas. This imaging technique can aid in detecting and monitoring active PTB alongside standard methods.
Area of Science:
- Nuclear Medicine
- Radiology
- Infectious Diseases
Background:
- Pulmonary tuberculosis (PTB) diagnosis relies on radiography and bacteriology.
- Novel imaging techniques are needed to complement existing diagnostic methods for PTB.
Purpose of the Study:
- To evaluate the utility of 99mTc-methoxyisobutylisonitrile (MIBI) scintigraphy for diagnosing and monitoring pulmonary tuberculosis (PTB).
- To compare MIBI scintigraphy findings with radiological and bacteriological results in PTB patients.
Main Methods:
- Thirty-six patients with known or suspected PTB underwent 99mTc-MIBI scintigraphy.
- Scans were performed 15 and 60 minutes post-injection of 99mTc-MIBI.
- Repeat imaging was conducted in 12 patients after chemotherapy.
Main Results:
- 92% of active PTB cases showed increased MIBI uptake.
- Miliary PTB cases exhibited diffuse lung uptake.
- MIBI scans demonstrated true-positive results in 80% of culture-proven relapsed PTB cases.
Conclusions:
- Active PTB granulomas typically show significant 99mTc-MIBI uptake, indicating disease activity.
- 99mTc-MIBI scintigraphy serves as a valuable adjunct for PTB detection and follow-up.
- The technique shows promise in monitoring treatment response and identifying potential drug resistance.