Related Experiment Video
Updated: Oct 13, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
[Fibrinolytic treatment in acute myocardial infarction: analysis of delay]
M L Iglesias1, J Pedro-Botet, E Hernández
1Servicios de Urgencias, Universidad Autónoma de Barcelona.
Insights
Delays in initiating fibrinolytic treatment for acute myocardial infarction (AMI) are significant, particularly intrahospital delays. Decision-making processes contribute most to the time lag, impacting patient outcomes.
Area of Science:
- Cardiology
- Emergency Medicine
- Clinical Research
Background:
- Acute myocardial infarction (AMI) requires timely intervention.
- Intravenous fibrinolytic therapy is a critical treatment for AMI.
- Understanding treatment delays is crucial for improving patient care.
Purpose of the Study:
- To analyze the delay times in initiating intravenous fibrinolytic treatment for AMI patients.
- To identify specific components contributing to total treatment delay.
- To evaluate factors influencing intrahospital delay in fibrinolysis administration.
Main Methods:
- A retrospective study of consecutive AMI patients treated at Hospital del Mar, Barcelona.
- Inclusion criteria: transmural AMI, age < 80 years, symptom onset < 6 hours.
- Analysis of total, extrahospitalary, and intrahospitalary delay times, including assistance, indication, and performance delays.
Main Results:
- Of 80 AMI patients, 33 received fibrinolytic treatment.
- Total delay time averaged 287.2 minutes.
- Intrahospitalary delay was 126.8 minutes, largely due to a 78.8-minute delay in treatment indication.
Conclusions:
- Decision delays significantly contribute to intrahospitalary delays in fibrinolytic treatment administration for AMI.
- Optimizing the decision-making process is key to reducing treatment times.
- Further research into streamlining treatment protocols is warranted.
Background:
The delay time from the onset of symptoms to the initiation of intravenous fibrinolytic treatment in patients with acute myocardial infarction (AMI) is herein described.
Methods:
A study was carried out of the consecutive AMI diagnosed in the Medical Area of the Emergency Department of the Hospital del Mar in Barcelona, Spain, with a 24-hour follow up from 15 May 1993 to 14 January, 1994. All the patients under the age of 80 years with transmural AMI of any localization and evolution of under 6 hours were considered to receive fibrinolytic treatment. The following delay times were analyzed: total delay time, extrahospitalary delay time and intrahospitalary delay time, which included assistance delay time, delay in fibrinolytic treatment indication and delay time in performance of the same.
Results:
During the study period 18,316 patients were attended in the Emergency Medical Area, of which 80 corresponded to AMI. Fibrinolytic treatment was initiated with intravenous streptokinase in 33 patients (41.3%). The total delay time was 287.2 +/- 202.6 (mean +/- SD) minutes; the extrahospitalary and intrahospitalary delays were 159.8 +/- 151.7 and 126.8 +/- 161.7 minutes, respectively. The delay time for assistance was 8.5 +/- 12.7 minutes, the delay time in treatment indication was 78.8 +/- 101.8 minutes and in performance it was 39.5 +/- 52.6 minutes. This latter time was analyzed on the basis of the administration site, with statistically significant differences (p < 0.005) if the fibrinolytic treatment was performed in the Emergency Medical Area (12.5 +/- 0.7 minutes), in the observation room (41.4 +/- 50.7 minutes) or in the Intensive Care Unit (61.4 +/- 75.8 minutes).
Conclusions:
Most of the intrahospitalary delay in the administration of fibrinolytic treatment is due to decision delay in regards to carrying out this therapy.
Related Concept Videos
Clot Retraction and Fibrinolysis
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Acute Coronary Syndrome I: Introduction
Acute Coronary Syndrome III: Diagnostic Studies
Acute Coronary Syndrome IV: Interprofessional Care

