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[Clinicopharmacological case report (3). Drug-induced angioedema]
B Kind1, K Fattinger, S Krähenbühl
1Abteilung Klinische Pharmakologie und Toxikologie, Departement Innere Medizin, Universitätsspital Zürich.
Praxis
|April 23, 1996
Abstract:
We report the case of a patient with an angioedema during therapy with enalapril and tramadol. The most likely cause of the adverse effect if the ACE-inhibitor enalapril. A rechallenge with the ACE-inhibitor is dangerous and should not be performed. Because of its potential risks, further treatment with ACE-inhibitors should be avoided in all patients with ACE-inhibitor-induced angioedema. Possible therapeutic alternatives include diuretics, beta-blocking agents, calcium antagonists and also angiotensin II receptor antagonists.