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Intracranial meningeal melanocytoma: case report
F Maiuri1, G Iaconetta, D Benvenuti
1Institute of Neurosurgery, School of Medicine, University of Naples "Federico II," Italy.
Surgical Neurology
|December 1, 1995
Summary
Meningeal melanocytoma, a benign tumor of the leptomeninges, originates from melanocytes. Complete surgical removal is the primary treatment, though prognosis remains uncertain due to potential local recurrences.
Area of Science:
- Neuropathology
- Oncology
Background:
- Meningeal melanocytoma is a rare, benign melanotic tumor arising from leptomeningeal melanocytes.
- These tumors can occur throughout the cranial and spinal meninges.
Observation:
- A case of meningeal melanocytoma involving the left sphenoid wing is presented.
- A review of nine previously reported cases is included.
Findings:
- Electron microscopy confirms melanin and melanosomes within tumor cells.
- Immunohistochemistry shows positivity for S-100 protein, vimentin, and antimelanoma antibody.
- The tumor is negative for epithelial membrane antigen, neuron-specific enolase, cytokeratin, and glial fibrillary acidic protein.
Implications:
- Complete surgical excision is the recommended treatment.
- Radiotherapy is generally not indicated.
- Despite its benign nature, the risk of local recurrence necessitates careful monitoring for an uncertain prognosis.